The ability to control mammalian cells such that they self-organize or enact therapeutic effects as desired has incredible implications.Not only would it further our understanding of native processes such as development and the immune response, but it would also have powerful applications in medical fields such as regenerative medicine and immunoth
Abdominal aortic aneurysm is a systemic and generalized arteriomegaly in mice and humans
Abstract Although the pathogenesis of abdominal aortic aneurysm (AAA) remains largely unclear, evidence is accumulating to suggest the systemic nature of this disease.Here, we comprehensively assessed the whole aortic tree with its major branches based on computed tomography angiography (CTA) in AAA patients compared to ascending thoracic aortic an
Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt
Abstract Background Many cancers arise from mutations in cells within epithelial tissues.Mutations manifesting at the subcellular level influence the structure and function of the tissue resulting Batteries in cancer.Previous work has proposed how cell level properties can lead to mutant cell invasion, but has not incorporated detailed subcellular